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KMID : 0545119990090050672
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Journal of Microbiology and Biotechnology
1999 Volume.9 No. 5 p.672 ~ p.674
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Immunosuppressive Activity of Cepacidine A,a Novel Antifungal Antibiotic Produced by Pseudomonas cepacia
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Lee, Chul Hoon
Suh, Jung Woo/Cho, Youl Hee
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Abstract
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Cepacidine A was first identified as a novel antifungal antibiotic which was isolated from the culture broth of Pseudomonas cepacia AF2001. It showed a potent in vitro antifungal activity against various pathogenic fungi, but did not show any activity against bacteria. Recently, the immunosuppressive action of cepacidine A was discovered using an in vitro screening system involving inhibition of the proliferation of murine lymphocytes stimulated by 2 mitogens, and also by in vivo mouse models involving inhibition of delayed type hypersensitivity and SRBC hemagglutination. Cepacidine A showed a significant activity of cellular immunosuppression (ED_50) at concentration levels of 1-3 ㎎/㎏, i.p.. Unfortunately, the delayed toxicity at a dose of above 3 ㎎/㎏ i.p. was apparent.
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